Chrysotile lung clearance
WebJun 1, 1992 · Our study used a very modest exposure to chrysotile (10 mg/m3 for 3 hr), which gives an initial lung burden of -10 ~g in the left lung (Table 2) or -30 ~tg for all … WebThe ratio of chrysotile and tremolite concentrations was significantly higher in the parietal pleura than in the lung (3.2 v 1.1, Wilcoxon matched pairs test, p = 0.016). The chrysotile and tremolite fibres were significantly thinner and shorter in …
Chrysotile lung clearance
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WebJun 27, 2008 · Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to amphibole … WebFeb 1, 2013 · Inhalation toxicity studies of chrysotile at non-lung overload conditions demonstrate that the long (>20 µm) fibers are rapidly cleared from the lung, are not translocated to the pleural cavity and do not initiate fibrogenic response.
WebClearance and dissolution kinetics for amphibole fibers are considerably slower than those for chrysotile in the lung ( 36, 38, 39 ), and these data might explain why chrysotile fibers are fewer, in comparison with amphibole types of asbestos, in the lungs of workers exposed primarily to chrysotile ( see Section 3). Webchrysotile fibres tend to fray, are very flexible and disintegrate if exposed to acids [12], thus accelerated clearance of inhaled chrysotile fibres from the lungs sounds plausible [13]. Although the hazardous nature of amphibole fibres is not challenged [8, 14], the impact of chrysotile fibres is a matter of discussion [15,
WebJun 1, 1992 · U.S. Department of Energy Office of Scientific and Technical Information. Search terms: Advanced search options. ... WebApr 1, 1997 · The lung burden analyses for all three fibre types show large reductions in number and volume of retained fibres during the 16 months following exposure. Most of this reduction in lung fibre burden occurred during the first 3 months following exposure but the pattern of clearance of different size classes varies with fibre type.
WebAnalysis of lung asbestos content indicates that induction of mesothelioma by chrysotile requires, on average, as great a lung fiber burden as induction ofmore » Tremolite alone …
WebApr 7, 2024 · This study was designed to determine lung clearance (biopersistence) and the histopathological response. As the long fibers have been shown to have the greatest … butler county tax servicesWebSignificant lung disease from Chrysotile typically presents after prolonged occupational exposure. Disease caused by Chrysotile typically manifests as pleural disease with primary progression evidenced by slowly increasing interstitial fibrosis. Chest pain and rapid progression are rare. cdc monkeypox interim guidanceWebJun 9, 2011 · Differential lung clearance between fibers of chrysotile and the more rod-like amphibole asbestos fibers was found in rats that underwent chronic inhalation exposures (Wagner et al., 1974). The lung fiber burdens of the amphiboles rose continuously throughout 2 yr of exposure, and declined slowly in the rats removed from exposure after … cdc monkeypox interim clinical considerationsWebIn rat studies, chrysotile asbestos and longer fibers (>5 μm) were more fibrogenic than shorter ones. Human. Chronic exposures to asbestos fibers cause nonmalignant and … cdc monkeypox patient intake formWebJun 1, 1992 · The serpentine chrysotile is a thin walled sheet silicate while the amphiboles are double-chain silicates. These different chemistries result in chrysotile clearing very rapidly from the lung (T 1/2 = 0.3 to 11 days) while amphiboles are among the slowest clearing fibers known (T 1/2 = 500 days to ∞). Across the range of mineral fiber ... cdc monkeypox intake formWebJun 1, 2024 · Certain chrysotile fibres which, like amphibole fibres, have successfully overcome the defence mechanisms of the lung and … cdc monkeypox pain managementWebOct 20, 2008 · Calidria chrysotile has been found to be one of the most rapidly cleared mineral fibers from the lung. The fibers longer than 20 μm in length are cleared with a half-time of 7 h. By 2 days postexposure all long fibers have dissolved/disintegrated into shorter pieces. The fibers between 5 and 20μm in length were cleared with a half-time of 7 days. butler county tax sales