Cisplatin prehydration

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August undefined, 2024

WebJan 11, 2024 · This information will help you hydrate yourself after getting high-dose cisplatin chemotherapy. Cisplatin can affect your kidneys. To keep your kidneys from … WebRepetitive doses of intravenous (IV) metoclopramide, 2 mg/kg in 75 ml 5% dextrose in water over 15 minutes was given 30 minutes prior to, and at 1 1/2, 4 1/2, and 7 1/2 hours after beginning cisplatin chemotherapy. Only patients with nausea and/or vomiting received subsequent doses of 2 mg/kg metoclopramide IV every 3 hours as needed.

Methimazole as a protectant against cisplatin-induced ... - PubMed

WebWe report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m (2) of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. WebMannitol combined with hydration significantly prevented cisplatin-induced nephrotoxicity. Additionally, mannitol should be particularly considered among patients with cancer, treated with cisplatin > 80 mg/m2, or patients receiving concomitant radiation. free timeshare rental listings

London Cancer Cisplatin Hydration Guideline v1 PDF

http://www.bccancer.bc.ca/chemotherapy-protocols-site/Documents/Neuro-Oncology/CNCCV_Protocol.pdf http://www.bccancer.bc.ca/chemotherapy-protocols-site/Documents/Lung/LUAJPP_Protocol.pdf WebAug 24, 2024 · A prospective cohort study evaluated magnesium (15 mEq) supplied as part of a prehydration regimen to 28 patients with cervical cancer receiving treatment with cisplatin. 9 There was no... farther date

Bleomycin, Etoposide and CISplatin (BEP) Therapy - Health …

Saline, mannitol, and furosemide hydration in acute …

WebMay 1, 2024 · Carboplatin Injection is supplied as a sterile, pyrogen-free, aqueous solution available in 50 mg/5 mL, 150 mg/15 mL, 450 mg/45 mL or 600 mg/60 mL multiple-dose vials containing 10 mg/mL of Carboplatin for administration by intravenous infusion. Each mL contains 10 mg Carboplatin and Water for Injection, USP. Webe Prehydration therapy required for CISplatin See local hospital policy recommendations. Suggested prehydration for CISplatin therapy: 1. Administer 10mmol magnesium sulphate (MgSO 4) ((+/-KCl 10-20mmol/L if indicated) in 1000 mL sodium chloride 0.9% over 60 minutes. Administer CISplatin as described above. free timesharesWebCISplatin/5-FU CISplatin 5-FU 5-FU as CIVI 46 CISplatin/Gemcitabine Gemcitabine CISplatin Less toxic 47 CISplatin/PACLitaxel PACLitaxel CISplatin Less neutropenia 48 CISplatin/PACLitaxel/Be vacizumab PACLitaxel CISplatin Bevacizumab All on Day 1, PACLitaxel over 3hrs. Sequence for efficacy and less toxicity. 49, 50 free timeshare vacation packages 2023

"WebJun 23, 2024 · Depending on the protocol, 1 - 2 litres pre-hydration. The patient must have urinated a litre minimum before we proceed. Our cisplat goes in 250 mls usually giving us a final volume of 340 mls. We used to pass Mannitol concurrently but that's now been … " - Cisplatin prehydration

Cisplatin prehydration

Web*Pre- and post-hydration protocol for high-dose CISplatin required according to institutional guidelines (eg, prehydration with 1 L NS over 1 hour, CISplatin in 500 mL NS with … WebObjective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who …

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WebJul 15, 2015 · Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many centers... WebCis-diamminedichloroplatinum II (cisplatin), a divalent platinum compound and potent cell-cycle nonspecific chemotherapeutic agent, produces a dose-limiting, permanent, high-frequency sensori-neural hearing loss and peripheral neuropathy, and a dose-related cumulative renal insufficiency with tubular necrosis and interstitial nephritis.

WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. WebCisplatin (CDDP) is one of the most active antineoplastic drugs prescribed to treat various solid tumors, including lung, gastric, head and neck, and bladder cancers. ... with or without an aprepitant, and was given before chemotherapy. For prehydration and posthydration, 5 mEq potassium chloride and 4 mEq magnesium sulfate in 500 mL of half ...

Webpractice in delivery of cisplatin. They should be individualized based on the clinical situation, which may affect the hydration regimen and addition of electrolytes. In children, … WebThe administration of 8 mg/Kg of DDP+NS produced a significantly better survival (P less than 0.05) compared to that observed in mice receiving DDP+DW. The proportion of long-term survivors was 3.5 times higher in the DDP+NS group (39%) compared to …

WebBackground The Children's Hospital of Eastern Ontario (CHEO) has implemented a rapid hydration protocol that may reduce the time required to achieve urine specific gravity and pH targets prior to chemotherapy. Objective The aim of this study was to determine if a rapid hydration protocol resulted in …

WebApr 24, 2024 · Hydration significantly reduces cisplatin half-life, urinary cisplatin concentrations, and proximal tubule transit time 10-12. Cisplatin can also cause high … farther distancesWebAbstract The protective effect of methimazole, a commonly used antithyroid drug, on cisplatin-induced nephrotoxicity was studied. Eight dogs received 80 mg/m2 cisplatin i.v. without saline prehydration. free timeshares for sale by ownerWebCisplatin can be detected in urine for weeks after a dose. III. DOSAGE AND ADMINISTRATION A) Administer as a short or long infusion but not IV push. B) Prehydration with 500 mL over 30 min - 2 hours, or 1000 mL NS over 2 - 4 hours. Compound the cisplatin in 500 mL NS and give over 1-2 hr. Post-hydration give 500- … farther down crosswordWeb75% (same prehydration as 75 mg/m² dose) less than 45 : Delay until creatinine clearance greater than 45 mL/min, then give 50% of CISplatin dose** **may reinstitute full dose CISplatin if renal function stable or improving after 2 more cycles . 3. Ototoxicity: Dose modifications required for CISplatin, Ototoxicity Dose (CISplatin) less than ... farther defineWeba Pre and post hydration therapy required for CISplatin See localhospital policy recommendations. Suggested prehydration for CISplatin therapy: • The administration of etoposide in 1000ml 0.9% NaCl over 1 hour as detailed above may be considered as pre-hydration for CISplatin • Administer CISplatin as described above Post hydration: free timeshares by ownerWebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the … farther down lyricshttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf free timeshare vacation packages caribbean